Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

H Zhang, L Liu, J Liu, P Dang, S Hu, W Yuan, Z Sun… - Molecular Cancer, 2023 - Springer
In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Targeting macrophages in cancer immunotherapy

Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells

S Ma, B Sun, S Duan, J Han, T Barr, J Zhang… - Nature …, 2023 - nature.com
Despite tumor-associated macrophages (TAMs) playing a key role in shaping the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …

Metabolic inflammation and insulin resistance in obesity

H Wu, CM Ballantyne - Circulation research, 2020 - Am Heart Assoc
Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …

Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics

A Carnicer-Lombarte, ST Chen… - … in Bioengineering and …, 2021 - frontiersin.org
The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …