The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Background: Dysregulated stress neurocircuits, caused by genetic and/or environmental
changes, underlie the development of many neuropsychiatric disorders. Corticotropin …

Background Insulin producing beta cell and glucagon producing alpha cells are colocalized
in pancreatic islets in an arrangement that facilitates the coordinated release of the two …

Insulin-expressing cells that have been differentiated from human pluripotent stem cells in
vitro lack the glucose responsiveness characteristic of mature beta cells. Beta-cell …

The peptide hormone urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its
physiological role is unknown. Here we demonstrate that Ucn3 is stored and co-released …

Sir2 NAD-dependent deacetylases connect transcription, metabolism, and aging. Increasing
the dosage or activity of Sir2 extends life span in yeast, worms, and flies and promotes fat …

G-protein coupled receptors (GPCRs) regulate hormone secretion from islets of Langerhans,
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …

Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

Dysfunction or death of pancreatic β cells underlies both types of diabetes. This functional
decline begins with β cell stress and de-differentiation. Current drugs for type 2 diabetes …

The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS,
including the modulation of the stress response. The ligands' effects are mediated by …