The healthy lung was long thought of as sterile, but recent advances using molecular
sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely …

Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …

We developed a metagenomic next-generation sequencing (mNGS) test using cell-free DNA
from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids …

Thousands of pathogens are known to infect humans, but only a fraction are readily
identifiable using current diagnostic methods. Microbial cell-free DNA sequencing offers the …

Seminal studies published in the 1990s and 2000s explored connections between
periodontal diseases and systemic conditions, revealing potential contributions of …

The characterization of the blood virome is important for the safety of blood-derived
transfusion products, and for the identification of emerging pathogens. We explored non …

Anelloviruses are a ubiquitous component of healthy human viromes and remain highly
prevalent after being acquired early in life. The full extent of" anellome" diversity and its …

Anelloviruses are small, single stranded circular DNA viruses. They are extremely diverse
and have not been associated with any disease so far. Strikingly, these small entities infect …

New reliable biomarkers are needed to improve individual risk assessment for post‐
transplant infection, acute graft rejection and other immune‐related complications after solid …

Potent immunosuppressive drugs have been introduced into clinical care for solid organ
transplant recipients. It is now time to guide these drugs on an individual level to optimize …