TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

The bacterial communities that collectively inhabit our body are called the microbiome.
Virtually all body surface harbors bacteria. Recent advances in next-generation sequencing …

Abstract Anti-Ro52 (or anti-TRIM21) antibodies are part of the family of anti-Ro/SSA
antibodies, historically markers of Sjögren syndrome and systemic lupus erythematosus …

Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterized by
dysfunction of secretory epithelia with only palliative therapy. Patients present with a …

Anti-SSA-autoantibodies are common in patients with rheumatologic disease, especially
Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis. They consist of …

Epitope mapping of anti-Ro52 antibodies (Abs) has been extensively studied in patients with
Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE). Comprehensive epitope …

Autoantibodies reactive against Ro52 are present in 70% of Sjögren's syndrome patients
and are associated with higher disease severity. However, their role in causing aqueous …

Background Salivary gland enlargement (SGE) is one of the common manifestations in
primary Sjögren's syndrome (pSS) patients who are first referred to the hospital of …

Background Oral and ocular dryness due to reduced saliva and tear production, exocrine
gland inflammation, and autoantibodies to multiple cellular proteins are the cardinal features …

Sjögren's syndrome (SS) is a systemic autoimmune disease affecting multiple organ
systems. Salivary and lacrimal gland involvement cause dry mouth and dry eye and are the …