Structure and mechanics of integrin-based cell adhesion

MA Arnaout, SL Goodman, JP Xiong - Current opinion in cell biology, 2007 - Elsevier
Integrins are α/β heterodimeric adhesion glycoprotein receptors that regulate a wide variety
of dynamic cellular processes such as cell migration, phagocytosis, and growth and …

[HTML][HTML] AFM for structure and dynamics of biomembranes

EI Goksu, JM Vanegas, CD Blanchette, WC Lin… - … et Biophysica Acta (BBA …, 2009 - Elsevier
We review structure and dynamic measurements of biomembranes by atomic force
microscopy (AFM). We focus mainly on studies involving supported lipid bilayers (SLBs) …

[HTML][HTML] Atomic force microscopy: a multifaceted tool to study membrane proteins and their interactions with ligands

AM Whited, PSH Park - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Membrane proteins are embedded in lipid bilayers and facilitate the communication
between the external environment and the interior of the cell. This communication is often …

Three-dimensional multi-scale model of deformable platelets adhesion to vessel wall in blood flow

Z Wu, Z Xu, O Kim, M Alber - … Transactions of the Royal …, 2014 - royalsocietypublishing.org
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming
a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel …

Asymmetric distribution of phosphatidyl serine in supported phospholipid bilayers on titanium dioxide

FF Rossetti, M Textor, I Reviakine - Langmuir, 2006 - ACS Publications
Supported phospholipid bilayers (SPBs) are useful for studying cell adhesion, cell− cell
interactions, protein− lipid interactions, protein crystallization, and applications in biosensor …

Hemocompatibility comparison of biomedical grade polymers using rabbit thrombogenicity model for preparing nonthrombogenic nitric oxide releasing surfaces

H Handa, TC Major, EJ Brisbois, KA Amoako… - Journal of Materials …, 2014 - pubs.rsc.org
Nitric oxide (NO) is an endogenous vasodilator as well as natural inhibitor of platelet
adhesion/activation. Nitric oxide releasing (NOrel) materials can be prepared by doping an …

Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force

RI Litvinov, V Barsegov, AJ Schissler, AR Fisher… - Biophysical journal, 2011 - cell.com
The regulated ability of integrin αIIbβ3 to bind fibrinogen plays a crucial role in platelet
aggregation, adhesion, and hemostasis. Employing an optical-trap-based electronic force …

Atomic force microscopy studies of the initial interactions between fibrinogen and surfaces

LC Xu, CA Siedlecki - Langmuir, 2009 - ACS Publications
Atomic force microscopy (AFM) was used to analyze the interactions between fibrinogen and
model surfaces having different levels of water wettability. In contrast to most AFM studies …

Experimental techniques to study protein dynamics and conformations

A Gupta, A Singh, N Ahmad, TP Singh… - Advances in Protein …, 2022 - Elsevier
Proteins are flexible biomolecules and can adopt a wide range of structural conformations
such that they can have their whole conformational ensemble. Understanding of protein …

Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets

S Mao, A Sarkar, Y Wang, C Song, D LeVine, X Wang… - Lab on a Chip, 2021 - pubs.rsc.org
Integrins are key players in platelet adhesion and aggregation. Integrin molecular tensions,
the forces transmitted by integrin molecules, are regulated by both mechanical and …