Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and
increases the risk of many aging-related metabolic diseases. Here, we report phenotypic …

Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …

Single-cell RNA-seq (scRNA-seq) has revolutionized modern genomics, but the large size of
myotubes and myofibers has restricted use of scRNA-seq in skeletal muscle. For the study of …

Sarcopenia is a progressive muscle wasting disorder that severely impacts the quality of life
of elderly individuals. Although the natural aging process primarily causes sarcopenia, it can …

Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which
causes numerous morbidities and economic burdens in human populations. Mechanisms …

In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage,
dysregulation of repair, fibro-fatty replacement, and weakness. We develop methodology to …

Plant single-cell RNA-seq technology quantifies the abundance of plant transcripts at a
single-cell resolution. Deciphering the transcriptomes of each plant cell, their regulation …