The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in …

V Norris, C Kayser, G Muskhelishvili… - FEMS Microbiology …, 2023 - academic.oup.com
How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

A single-molecule approach to unravel the molecular mechanism of the action of Deinococcus radiodurans RecD2 and its interaction with SSB and RecA in DNA …

D Purkait, F Islam, PP Mishra - International Journal of Biological …, 2022 - Elsevier
Helicases are ATP-driven molecular machines that directionally remodel nucleic acid
polymers in all three domains of life. They are responsible for resolving double-stranded …

Molecular Insight into the Structural Dynamics of Holliday Junctions Modulated by Integration Host Factor

F Islam, PP Mishra - The Journal of Physical Chemistry B, 2024 - ACS Publications
The integration host factor (IHF) in Escherichia coli is a nucleoid-associated protein with
multifaceted roles that encompass DNA packaging, viral DNA integration, and …

Unveiling the Holliday junction conformational dynamics of upon binding with DNA architectural proteins IHF; A Single molecule FRET approach

F Islam, PP Mishra - bioRxiv, 2023 - biorxiv.org
Integration host factor (IHF) of E. coli is a nucleoid-associated protein with diverse roles in
DNA packaging, viral DNA integration, and recombination. IHF binds to duplex DNA …

[PDF][PDF] Hypothesis: bacteria live on the edge of phase transitions with a cell cycle regulated by a water-clock

VNC UR - 2024 - scholar.archive.org
A fundamental problem in biology is how cells obtain the reproducible, coherent phenotypes
needed for natural selection to act or, put differently, how cells manage to limit their …

Probing the molecular mechanism of the action of Deinococcus radiodurans RecD2 at single-molecule resolution

D Purkait, F Islam, PP Mishra - bioRxiv, 2021 - biorxiv.org
Helicases are ATP-driven molecular machines that directionally remodel nucleic acid
polymers in all three domains of life. Helicases are responsible for resolving double …