Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK/STAT3, MAPK/ERK, and AKT/mTOR signaling pathways in HepG2 …
Hepatocellular carcinoma is a common cancer type, especially among men. Although
cucurbitacin I (CuI), widely found in plants belonging to the Ecballium elaterium (E. L) plant …
cucurbitacin I (CuI), widely found in plants belonging to the Ecballium elaterium (E. L) plant …
A review on pharmacological activities of Citrullus colocynthis (L.) Schrad
MSK Meybodi - Asian journal of Research and Reports …, 2020 - journal.article2publish.com
Plants are seen generally as resources for food and medicines by humans. Citrullus
colocynthis is a decorative European plant. It belongs to the Cucurbitaceae family and is …
colocynthis is a decorative European plant. It belongs to the Cucurbitaceae family and is …
GANE can improve lung fibrosis by reducing inflammation via promoting p38MAPK/TGF-β1/NF-κB signaling pathway downregulation
There is a trend to use nanoparticles as distinct treatments for cancer treatment because
they have overcome many of the limitations of traditional drug delivery systems. Gallic acid …
they have overcome many of the limitations of traditional drug delivery systems. Gallic acid …
Synthetic Modifications of Therapeutically Relevant Pre-assembled Cucurbitacins: Synthetic Strategies and Structure-Activity Relationships
R Sharma, S Thakur, M Kumar, K Vamsi… - Journal of Molecular …, 2024 - Elsevier
Cucurbitacins are natural products of the Cucurbitaceae family (cucumber, melon, gourd,
etc.) and contain cucurbitane skeleton. They are oxygenated triterpenoids containing three …
etc.) and contain cucurbitane skeleton. They are oxygenated triterpenoids containing three …
A novel quinazoline-4-one derivatives as a promising cytokine inhibitors: Synthesis, molecular docking, and structure-activity relationship
RM Borik, MA Hussein - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
Background: Quinazolines are a common class of nitrogen-containing heterocyclic scaffolds,
which exhibit a broad spectrum of pharmacological activities. Objectives: In the present …
which exhibit a broad spectrum of pharmacological activities. Objectives: In the present …
Cucurbitacin D inhibits the proliferation of HepG2 cells and induces apoptosis by modulating JAK/STAT3, PI3K/Akt/mTOR and MAPK signaling pathways
Background: Cucurbitacin D (CuD) is a natural compound that can be isolated in various
plant families, mainly from Ecballium elaterium (L.) A. Rich.(E. elaterium). It is a triterpenoid …
plant families, mainly from Ecballium elaterium (L.) A. Rich.(E. elaterium). It is a triterpenoid …
Biological activities, isolated compounds and HPLC profile of Verbascum nubicum
HAEH El Gizawy, MA Hussein… - Pharmaceutical …, 2019 - Taylor & Francis
Abstract Context: Genus Verbascum (Scrophulariaceae) comprises about 360 species of
flowering plants. Verbascum has been used in traditional medicine as an astringent …
flowering plants. Verbascum has been used in traditional medicine as an astringent …
Synergistic effect of cucurbitacin E and myricetin on Anti-Non-Small cell lung cancer: Molecular mechanism and therapeutic potential
J Zhang, B Aray, Y Zhang, Y Bai, T Yuan, S Ding, Y Xue… - Phytomedicine, 2023 - Elsevier
Background Non-small cell lung cancer (NSCLC) is associated with extremely high
morbidity and mortality rates worldwide. Citrullus colocynthis (L.) Schrad, widely distributed …
morbidity and mortality rates worldwide. Citrullus colocynthis (L.) Schrad, widely distributed …
Phytochemistry, Toxicity and Pharmacology of Pistacia lentiscus, Artemisia herba-alba and Citrullus colocynthis
MA Gacem, A Ould El Hadj-Khelil, B Boudjemaa… - … Agriculture Reviews 39, 2020 - Springer
Pistacia lentiscus, Artemisia herba-alba and Citrullus colocynthis are medicinal plants
known for a long time in herbal medicine. Here we review their bioactive substances and …
known for a long time in herbal medicine. Here we review their bioactive substances and …
The mechanisms of cucurbitacin E as a neuroprotective and memory-enhancing agent in a cerebral hypoperfusion rat model: attenuation of oxidative stress …
Impaired cerebral hemodynamic autoregulation, vasoconstriction, and cardiovascular and
metabolic dysfunctions cause cerebral hypoperfusion (CH) that triggers pro-oxidative and …
metabolic dysfunctions cause cerebral hypoperfusion (CH) that triggers pro-oxidative and …