Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

The calcium-binding protein calmodulin (CaM) directly binds to membrane transport proteins
to modulate their function in response to changes in intracellular calcium concentrations …

In response to Ca2+ signals, the evolutionarily‐conserved Ca2+ sensor calmodulin (CaM)
regulates protein targets via direct interaction. Plants possess many CaM‐like (CML) …

Voltage-gated calcium (Cav) channels serve dual roles in the cell, where they can both
depolarize the membrane potential for electrical excitability, and activate transient …

B cell lymphoma-2 (BCL-2)-related proteins control programmed cell death through a
complex network of protein–protein interactions mediated by BCL-2 homology 3 (BH3) …

Voltage-gated Na and Ca2+ channels represent two major ion channel families that enable
myriad biological functions including the generation of action potentials and the coupling of …

Openings of high-voltage-activated (HVA) calcium channels lead to a transient increase in
calcium concentration that in turn activate a plethora of cellular functions, including muscle …

Programmed cell death (PCD) plays an important role in plant environmental stress and has
the potential to be manipulated to enhance disease resistance. Plants have innate immunity …

The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was
a limiting factor in the evolution of nervous systems. Two rounds of domain duplications …