Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible
to these diseases than males. Here, we analyzed human thymic transcriptome and revealed …

Advancements in the field of biomedicine, including the control of infectious diseases
through antibiotics and vaccination practices and the prevention of chronic disorders, have …

About two decades ago, cloning of the autoimmune regulator (AIRE) gene materialized one
of the most important actors on the scene of self-tolerance. Thymic transcription of genes …

Aging is associated with DNA accumulation and increased homeostatic proliferation of
circulating T cells. Although these attributes are associated with aging-related autoimmunity …

Interference with immune cell proliferation represents a successful treatment strategy in T
cell–mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis …

Thymic involution and the subsequent amplified release of autoreactive T cells increase the
susceptibility toward developing autoimmunity, but whether they induce chronic …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the global
pandemic of coronavirus disease 2019 (COVID-19) and particularly exhibits severe …

T cell recognition of unknown antigens relies on the tremendous diversity of the T cell
receptor (TCR) repertoire; generation of which can only occur in the thymus. TCR repertoire …