Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …

Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2)
protein, comprise the predominant genetic cause of Parkinson's disease (PD). G2019S, the …

Nowadays, there is an increasing concern regarding traumatic brain injury (TBI) worldwide
since substantial morbidity is observed after it, and the long-term consequences that are not …

Abstract Leucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the
treatment of Parkinson's disease (PD), is highly expressed in monocytes and macrophages …

Background Traumatic brain injury (TBI) produces a series of pathological processes.
Recent studies have indicated that autophagy pathway is persistently activated after TBI …

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive
impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD …

Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause
of familial and sporadic Parkinson's disease (PD). Elevated kinase activity is associated with …

Diabetic retinopathy (DR) is a common complication in patients with diabetes and has
become an important cause of blindness in working-age people. However, the mechanisms …

Leucine-rich repeat kinase 2 (LRRK2) is one of the most commonly mutated genes in
familial Parkinson's disease (PD). Under some circumstances, LRRK2 co-localizes with …

The Parkinson disease (PD) genetic LRRK2 gain-of-function mutations may relate to the ER
pathological changes seen in PD patients at postmortem. Human induced pluripotent stem …