Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

The transcriptional co-regulators YAP and TAZ pair primarily with the TEAD family of
transcription factors to elicit a gene expression signature that plays a prominent role in …

The Hippo pathway plays an important role in regulating tissue homeostasis, and its
effectors, the transcriptional co-activators Yes-associated protein (YAP) and WW domain …

The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …

The Hippo signaling pathway was initially defined by genetic studies in Drosophila to
regulate tissue growth and organ size [1, 2]. This pathway is highly conserved in mammals …

The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal
transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ …

TAZ is a WW domain containing a transcription coactivator that modulates mesenchymal
differentiation and development of multiple organs. In this study, we show that TAZ is …