Abstract Error-corrected Next Generation Sequencing (ecNGS) is rapidly emerging as a
valuable, highly sensitive and accurate method for detecting and characterizing mutations in …

The ability to accurately measure mutations is critical for basic research and identifying
potential drug and chemical carcinogens. Current methods for in vivo quantification of …

Cascade reactions are often 'employed'by nature to construct structurally diverse nitrogen-
containing heterocycles in a highly stereoselective fashion, ie, secondary metabolites …

Exposure to environmental mutagens increases the risk of cancer and genetic disorders. We
used Duplex Sequencing (DS), a high-accuracy error-corrected sequencing technology, to …

Mutagenicity testing is an essential component of health safety assessment. Duplex
Sequencing (DS), an emerging high-accuracy DNA sequencing technology, may provide …

Abstract Error-corrected Duplex Sequencing (DuplexSeq) enables direct quantification of
low-frequency mutations and offers tremendous potential for chemical mutagenicity …

Simple Summary Colorectal cancer is a highly lethal cancer type with a high incidence and
mortality rate in Hungary. To explore the genetic background behind this epidemiological …

Dietary exposure to aflatoxin B1 (AFB1) is a risk factor for the development of hepatocellular
carcinomas. Following metabolic activation, AFB1 reacts with guanines to form covalent …

Quantitative risk assessments of chemicals are routinely performed using in vivo data from
rodents; however, there is growing recognition that non‐animal approaches can be human …

The lacZ gene of Escherichia coli encodes β-galactosidase (β-gal), a lactose metabolism
enzyme of the lactose operon. Previous chemical modification or site-directed mutagenesis …