Diabetes compromises bone cell metabolism and function, resulting in increased risk of
fragility fracture. Advanced glycation end products (AGEs) interact with the receptor for AGEs …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

There is growing evidence that the higher fracture rate observed in patients with type 2
diabetes mellitus (T2DM) is associated with normal, or even increased, areal bone mineral …

In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

Data have accumulated to show that various types of collagen crosslinking are implicated in
the health of individuals, as well as in a number of disease states, such as osteoporosis …

Diabetes increases risk of fracture, although type 2 diabetes is characterized by normal or
high bone mineral density (BMD) compared with the patients without diabetes. The fracture …

Abstract Purpose of the Review Diabetes mellitus is a chronic metabolic disorder commonly
encountered in orthopedic patients. Both type 1 and type 2 diabetes mellitus increase …

Substantial evidence exists that in addition to the well-known complications of diabetes,
increased fracture risk is an important morbidity. This risk is probably due to altered bone …

The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma
(PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance …

Osteoporosis is a skeletal disease characterized by decreased bone mass and
microarchitectural changes in bone tissue that increase the susceptibility to fracture …