Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …
[PDF][PDF] Why does obesity cause diabetes?
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …
A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives
J Reed, S Bain, V Kanamarlapudi - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …
metabolic disease largely characterised by impaired insulin secretion and action. Significant …
The Lancet Commission on diabetes: using data to transform diabetes care and patient lives
Executive summary 2020 will go down in history as the year when the global community was
awakened to the fragility of human health and the interdependence of the ecosystem …
awakened to the fragility of human health and the interdependence of the ecosystem …
Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
DL Eizirik, L Pasquali, M Cnop - Nature Reviews Endocrinology, 2020 - nature.com
Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …
MicroRNA-mediated regulation of glucose and lipid metabolism
P Agbu, RW Carthew - Nature reviews Molecular cell biology, 2021 - nature.com
In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …
[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
[HTML][HTML] The effects of type 2 diabetes mellitus on organ metabolism and the immune system
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes …
AJ Garber, Y Handelsman, G Grunberger, D Einhorn… - Endocrine Practice, 2020 - Elsevier
ABSTRACT Abbreviations: A1C= hemoglobin A1C; AACE= American Association of Clinical
Endocrinologists; ABCD= adiposity-based chronic disease; ACCORD= Action to Control …
Endocrinologists; ABCD= adiposity-based chronic disease; ACCORD= Action to Control …
Oxidative stress and diabetes: antioxidative strategies
Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …