Animal models contribute greatly to our understanding of brain development and function as
well as its dysfunction in neurological diseases. Epilepsy research is a very good example of …

This article discusses the potential of Zebrafish (ZF)(Danio Rerio), as a model for epilepsy
research. Epilepsy is a neurological disorder affecting both children and adults, and many …

Understanding the physiological mechanisms that limit animal thermal tolerance is crucial in
predicting how animals will respond to increasingly severe heat waves. Despite their …

Brain activity and connectivity alter drastically during epileptic seizures. The brain networks
shift from a balanced resting state to a hyperactive and hypersynchronous state. It is …

Potassium ion (K+) concentration fluctuates in various biological processes. A number of K+
probes have been developed to monitor such fluctuations through optical imaging. However …

Seizures are characterized by hypersynchronization of neuronal networks. Understanding
these networks could provide a critical window for therapeutic control of recurrent seizure …

Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …

Sleep pressure increases during wake and dissipates during sleep, but the molecules and
neurons that measure homeostatic sleep pressure remain poorly understood. We present a …

The ability to directly observe leukocyte behavior in vivo has dramatically expanded our
understanding of the immune system. Zebrafish are particularly amenable to the high …

Pathophysiological explanations of epilepsy typically focus on either the micro/mesoscale
(eg excitation-inhibition imbalance), or on the macroscale (eg network architecture). Linking …