[HTML][HTML] Engaging innate immunity in HIV-1 cure strategies
Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …
[HTML][HTML] Small but Highly Versatile: The Viral Accessory Protein Vpu
M Volcic, L Wiesmüller, F Kirchhoff - Annual Review of Virology, 2023 - annualreviews.org
Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …
[HTML][HTML] Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers
MG Pauthner, JP Nkolola, C Havenar-Daughton… - Immunity, 2019 - cell.com
Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from
hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge …
hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge …
[HTML][HTML] Human non-neutralizing HIV-1 envelope monoclonal antibodies limit the number of founder viruses during SHIV mucosal infection in rhesus macaques
S Santra, GD Tomaras, R Warrier, NI Nicely… - PLoS …, 2015 - journals.plos.org
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus
across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies …
across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies …
[HTML][HTML] An asymmetric opening of HIV-1 envelope mediates antibody-dependent cellular cytotoxicity
The HIV-1 envelope glycoprotein (Env)(gp120-gp41) 3 is the target for neutralizing
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …
Antibody-dependent cellular cytotoxicity in HIV infection
DN Forthal, A Finzi - Aids, 2018 - journals.lww.com
Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as
natural killer cells, monocytes, macrophages and neutrophils can potentially mediate …
natural killer cells, monocytes, macrophages and neutrophils can potentially mediate …
[HTML][HTML] Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120
Summary While HIV-1-mediated CD4 downregulation protects infected cells from antibody-
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …
dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander …
CD4 mimetics sensitize HIV-1-infected cells to ADCC
J Richard, M Veillette, N Brassard… - Proceedings of the …, 2015 - National Acad Sciences
HIV-1-infected cells presenting envelope glycoproteins (Env) in the CD4-bound
conformation on their surface are preferentially targeted by antibody-dependent cell …
conformation on their surface are preferentially targeted by antibody-dependent cell …
[HTML][HTML] Immunological approaches to HIV cure
Combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV)
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
[HTML][HTML] Targeting HIV reservoir in infected CD4 T cells by dual-affinity re-targeting molecules (DARTs) that bind HIV envelope and recruit cytotoxic T cells
DD Sloan, CYK Lam, A Irrinki, L Liu, A Tsai… - PLoS …, 2015 - journals.plos.org
HIV reservoirs and production of viral antigens are not eliminated in chronically infected
participants treated with combination antiretroviral therapy (cART). Novel therapeutic …
participants treated with combination antiretroviral therapy (cART). Novel therapeutic …