The brain vasculature has been increasingly recognized as a key player that directs brain
development, regulates homeostasis, and contributes to pathological processes. Following …

Rodent stroke models provide the experimental backbone for the in vivo determination of the
mechanisms of cell death and neural repair, and for the initial testing of neuroprotective …

With continued debate over the functional significance of adult neurogenesis, identifying an
in vivo correlate of neurogenesis has become an important goal. Here we rely on the …

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

The dynamics of BBB permeability after AIS in humans are not well understood. In the
present study we measured the evolution of BBB permeability after AIS in humans using …

Recovery of function after stroke is thought to be dependent on the reorganization of
adjacent, surviving areas of the brain. Macroscopic imaging studies (functional magnetic …

Matrix metalloproteinases (MMPs) are matrix‐degrading enzymes involved in diverse
homeostatic and pathological processes. Several MMPs are expressed within the CNS and …

Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …

Stroke is a leading cause of adult disability. Stem/progenitor cell transplantation improves
recovery after stroke in rodent models. These studies have 2 main limitations to clinical …

Stroke is the leading cause of adult disability with≈ 80% being ischemic. Stem cell
transplantation has been shown to improve functional recovery. However, the overall …