Heterogeneity of patients with intermediate (BCLC B) Hepatocellular Carcinoma: proposal for a subclassification to facilitate treatment decisions

L Bolondi, A Burroughs, JF Dufour… - Seminars in liver …, 2012 - thieme-connect.com
The intermediate stage of hepatocellular carcinoma (HCC) comprises a highly
heterogeneous patient population and therefore poses unique challenges for therapeutic …

[HTML][HTML] HCC and angiogenesis: possible targets and future directions

AX Zhu, DG Duda, DV Sahani, RK Jain - Nature reviews Clinical …, 2011 - nature.com
Hepatocellular carcinoma (HCC), the most common primary liver tumor, is notoriously
resistant to systemic therapies, and often recurs even after aggressive local therapies. HCCs …

Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular …

M Kudo, K Ueshima, M Ikeda, T Torimura, N Tanabe… - Gut, 2020 - gut.bmj.com
Objective This trial compared the efficacy and safety of transarterial chemoembolisation
(TACE) plus sorafenib with TACE alone using a newly established TACE-specific endpoint …

Lenvatinib as an initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteria and Child–Pugh a liver function: a proof-of …

M Kudo, K Ueshima, S Chan, T Minami, H Chishina… - Cancers, 2019 - mdpi.com
Although transcatheter arterial chemoembolization (TACE) is the standard of care for
intermediate-stage hepatocellular carcinoma (HCC), this is a largely heterogeneous disease …

Final results of TACTICS: a randomized, prospective trial comparing transarterial chemoembolization plus sorafenib to transarterial chemoembolization alone in …

M Kudo, K Ueshima, M Ikeda, T Torimura, N Tanabe… - Liver cancer, 2022 - karger.com
Introduction: Several clinical trials comparing the efficacy and safety of transarterial
chemoembolization (TACE) plus molecular-targeted agents versus TACE alone revealed no …

[PDF][PDF] Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma: a randomized phase III trial

M Kudo, G Han, RS Finn, RTP Poon, JF Blanc… - …, 2014 - Wiley Online Library
Transarterial chemoembolization (TACE) is the current standard of treatment for
unresectable intermediate‐stage hepatocellular carcinoma (HCC). Brivanib, a selective dual …

Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma

M Kudo, K Imanaka, N Chida, K Nakachi… - European journal of …, 2011 - Elsevier
BACKGROUND: In Japan and South Korea, transarterial chemoembolisation (TACE) is an
important locoregional treatment for patients with unresectable hepatocellular carcinoma …

Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: available evidence and expert opinion on the use of transarterial …

JL Raoul, B Sangro, A Forner, V Mazzaferro… - Cancer treatment …, 2011 - Elsevier
Transarterial chemoembolization (TACE) is considered the gold standard for treating
intermediate-stage hepatocellular carcinoma (HCC). However, intermediate-stage HCC …

Local-regional treatment of hepatocellular carcinoma

R Lencioni, L Crocetti - Radiology, 2012 - pubs.rsna.org
Local-regional treatments play a key role in the management of hepatocellular carcinoma
(HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC …

Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics

R Dhanasekaran, A Limaye… - … medicine: evidence and …, 2012 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a common malignancy in developing countries and its
incidence is on the rise in the developing world. The epidemiology of this cancer is unique …