Abstract Glycogen synthase kinase 3 (GSK-3) dysregulation plays an important role in the
pathogenesis of numerous disorders, affecting the central nervous system (CNS) …

The number of known pathologies involving deregulated Tau expression/metabolism is
increasing. Indeed, in addition to tauopathies, which comprise approximately 30 diseases …

Cognitive abnormalities are common in Parkinson's disease, with important social and
economic implications. Factors influencing their evolution remain unclear but are crucial to …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of
Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates …

Five genes have been identified that contribute to Mendelian forms of Parkinson disease
(PD); however, mutations have been found in fewer than 5% of patients, suggesting that …

Tau is a microtubule-associated protein linked with neurodegenerative diseases. Humans
express six different isoforms of tau; the longest containing four microtubule-binding repeat …

Cytoskeletal homeostasis is essential for the development, survival and maintenance of an
efficient nervous system. Microtubules are highly dynamic polymers important for neuronal …

Genome-wide association study (GWAS) has seen great strides in revealing initial insights
into the genetic architecture of Parkinson's disease (PD). Since GWAS signals often reside …

Parkinson's Disease (PD) is a progressive neurodegenerative disorder with no cure. Clinical
presentation is characterized by postural instability, resting tremors, and gait problems that …

In view of the population-specific heterogeneity in reported genetic risk factors for
Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a …