Inositol is an essential nutrient, obtained either by uptake from the environment or by de
novo synthesis from glucose. Inositol and its derivatives exhibit tumor-suppressive effects …

Metabolic reprogramming is one of the hallmarks of tumor. Growing evidence suggests
metabolic changes that support oncogenic progression may cause selective vulnerabilities …

Inositol plays a significant role in cellular function and signaling. Studies in yeast have
demonstrated an “inositol-less death” phenotype, suggesting that inositol is an essential …

Inositol monophosphatase (IMPase) is an enzyme with two homologs—IMPA1 and IMPA2—
that is responsible for dephosphorylating myo-inositol monophosphate to generate myo …

Cancer stem cells (CSCs) play a central role in ovarian cancer (OC), understanding
regulatory mechanisms governing their stemness is critical. Here, we report ISYNA1, the rate …

Clinical data from over two decades, involving more than 3000 treated patients, demonstrate
that adeno‐associated virus (AAV) gene therapy is a safe, effective, and well‐tolerated …

Identification of novel molecular signaling targets for non-small cell lung cancer (NSCLC) is
important. The present study examined expression, functions and possible underlying …

Beneficial effects of sodium glucose co-transporter 2 inhibitors (SGLT2is) in cardiovascular
diseases have been extensively reported leading to the inclusion of these drugs in the …

Acute myeloid leukemia (AML) is a heterogeneous and deadly disease characterized by
uncontrolled expansion of malignant blasts. Altered metabolism and dysregulated …

RNA therapeutics are emerging as a unique opportunity to drug currently “undruggable”
molecules and diseases. While their advantages over conventional, small molecule drugs …