Simple Summary The cytoskeleton is a network of protein fibres within cells that provide
structure and support intracellular transport. Focal adhesions are protein complexes …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

Currently> 50 proteins have been reported to be associated with focal contacts and related
ECM adhesions. Most of these contain multiple domains through which they can interact …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

▪ Abstract Ena/VASP proteins are a conserved family of actin regulatory proteins made up of
EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin …

Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more
than 15 proteins. Biochemical and structural analyses have contributed to detailed …

Endothelium forms a semi-permeable barrier that separates blood from the underlying
tissue. Barrier function is largely determined by cell-cell and cell-matrix adhesions that …

Intracellular propulsion of Listeria monocytogenes is the best understood form of motility
dependent on actin polymerization. We have used in vitro motility assays of Listeria in …

Cells sustain high rates of actin filament elongation by maintaining a large pool of actin
monomers above the critical concentration for polymerization. Profilin–actin complexes …