Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Conspectus Glycosaminoglycans (GAGs) are a family of structurally complex
heteropolysaccharides composed of alternating hexosamine and uronic acid or galatose …

Nucleotide sugars have essential roles in every living creature. They are the building blocks
of the biosynthesis of carbohydrates and their conjugates. They are involved in processes …

Metabolic labeling of glycans with clickable unnatural sugars has enabled glycan analysis in
multicellular systems. However, cell-type-specific labeling of glycans in vivo remains …

Highlights•Metabolic engineering of heparosan, heparin and heparan sulfate•Chemical and
chemoenzymatic synthesis of low molecular weight heparins•Development of new heparin …

Sugar nucleotides are essential glycosylation donors in the carbohydrate metabolism.
Naturally, most sugar nucleotides are derived from a limited number of common sugar …

Core fucosylation and O-GlcNAcylation are the two most famous protein glycosylation
modifications that regulate diverse physiological and pathological processes in living …

For decades, researchers have endeavored to develop a general automated system to
synthesize oligosaccharides that is comparable to the preparation of oligonucleotides and …

Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …

Azido sugars have found frequent use as probes of biological systems in approaches
ranging from cell surface metabolic labeling to activity-based proteomic profiling of …