Because mutations, overexpression, and dysregulation of protein kinases play essential
roles in the pathogenesis of many illnesses, this enzyme family has become one of the most …

Background and Aim: Pancreatic cancer is one of the most fatal cancers. Cytotoxic
chemotherapy remains the mainstream treatment for unresectable pancreatic cancer. This …

Combination therapy has become a cornerstone in cancer treatment to potentiate
therapeutic effectiveness and overcome drug resistance and metastasis. In this work, we …

The present study is aimed to formulate lapatinib nanosponges (LPT NSs) to enhance its
aqueous solubility and bioavailability. LPT loaded NSs were fabricated using Eudragit …

Abstract Purpose of Review Leptomeningeal disease (LMD) is a rare, late complication of
systemic cancer and is associated with significant neurological morbidity and high mortality …

Objective (s): Mouse breast cancer cell line 4T1 can accurately mimic the response to
immune receptors and targeting therapeutic agents. Combined therapy has emerged as an …

Background Physical activity may increase the risk of cardiotoxicity (myocardial ischemia,
major arrhythmias) of 5-Fluorouracil, but this risk has never been investigated for its prodrug …

The objective of this study was to determine associations of paraoxonase-1 (PON-1) with
development of cancer therapy–related cardiac dysfunction (CTRCD). PON-1 is a …

The role of the epidermal growth factor receptor (EGFR) in tumor progression and survival is
often underplayed. Its expression and/or dysregulation is associated with disease …

Receptor tyrosine kinases (RTKs) play key roles in various aspects of cell biology, including
cell-to-cell communication, proliferation and differentiation, survival, and tissue homeostasis …