RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases …

Ras proteins assemble into transient nanoclusters on the plasma membrane. Nanoclusters
are the sites of Ras effector recruitment and activation and are therefore essential for signal …

K-RAS4B (Kirsten rat sarcoma viral oncogene homolog 4B) is a prenylated, membrane-
associated GTPase protein that is a critical switch for the propagation of growth factor …

RAS is a signaling protein associated with the cell membrane that is mutated in up to 30% of
human cancers. RAS signaling has been proposed to be regulated by dynamic …

How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas,
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …

K-Ras is a membrane-associated GTPase that cycles between active and inactive
conformational states to regulate a variety of cell signaling pathways. Somatic mutations in K …

By the end of the 19th century British and French oceanographic expeditions had shown that
life exists in the deepest ocean trenches. Since then, microorganisms have been found to …

Activation of RAF kinase involves the association of its RAS-binding domain (RBD) and
cysteine-rich domain (CRD) with membrane-anchored RAS. However, the overall …

The primary site of Ras signal transduction is the plasma membrane (PM). On the PM, the
ubiquitously expressed Ras isoforms, H-, N-, and K-Ras, spatially segregate to …

Ras proteins require membrane association for proper function. This process is tightly
regulated by reversible palmitoylation that controls not only the distribution over different …