Seven mobile oxazolidinone resistance genes, including cfr, cfr (B), cfr (C), cfr (D), cfr (E),
optrA, and poxtA, have been identified to date. The cfr genes code for 23S rRNA methylases …

The definition of the heterogeneous group of coagulase-negative staphylococci (CoNS) is
still based on diagnostic procedures that fulfill the clinical need to differentiate between …

Antimicrobial resistance is a normal evolutionary process for microorganisms. Antibiotics
exerted accelerated selective pressure that hasten bacterial resistance through mutation …

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE
infections are difficult to treat since common therapeutic options including ampicillin and …

Antibiotics—compounds that are literally 'against life'—are typically antibacterial drugs,
interfering with some structure or process that is essential to bacterial growth or survival …

Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections
of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl …

Many clinically useful antibiotics exert their antimicrobial effects by blocking protein
synthesis on the bacterial ribosome. The structure of the ribosome has recently been …

Abuse of antibiotics has led to the emergence of drug-resistant pathogens. Methicillin-
resistant Staphylococcus aureus (MRSA) was reported just two years after the clinical use of …

TO THE EDITOR: In his review of linezolid, Moellering (1) appropriately calls for clinical trials
comparing the efficacy and safety of linezolid with those of other new drugs active against …

Protein synthesis is one of the major targets in the cell for antibiotics. This review endeavors
to provide a comprehensive “post-ribosome structure” A–Z of the huge diversity of antibiotics …