By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Cerebral palsy is a sporadic disorder with multiple likely aetiologies, but frequently
considered to be caused by birth asphyxia. Genetic investigations are rarely performed in …

Kv1. 1 belongs to the Shaker subfamily of voltage-gated potassium channels and acts as a
critical regulator of neuronal excitability in the central and peripheral nervous systems …

Abstract Episodic ataxia type 1 (EA1) is an autosomal dominant central nervous system
potassium channelopathy characterized by brief attacks of cerebellar ataxia and continuous …

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …

Objective: To identify the causative gene in spinocerebellar ataxia (SCA) 22, an autosomal
dominant cerebellar ataxia mapped to chromosome 1p21‐q23. Methods: We previously …

This review addresses the molecular and cellular mechanisms of diseases caused by
inherited mutations of ion channels in neurones. Among important recent advances is the …

Dendrotoxins are small proteins isolated from mamba (Dendroaspis) snakes. The original
dendrotoxin was found in venom of the Eastern green mamba, Dendroaspis angusticeps …

Abstract Episodic ataxia type-1 (EA1) is a dominant human neurological disorder
characterized by stress-induced attacks of ataxia. EA1 is caused by mutations in the voltage …