Targeting eosinophils in allergy, inflammation and beyond

PC Fulkerson, ME Rothenberg - Nature reviews Drug discovery, 2013 - nature.com
Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

TX Lu, ME Rothenberg - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Allergic inflammation is accompanied by the coordinated expression of a myriad of genes
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling …

Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial

JM Spergel, ME Rothenberg, MH Collins… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic esophagitis is a chronic allergic disease with insufficient
treatment options. Results from animal studies suggest that IL-5 induces eosinophil …

Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis

ES Alexander, LJ Martin, MH Collins, LC Kottyan… - Journal of allergy and …, 2014 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic antigen-driven allergic inflammatory
disease, likely involving the interplay of genetic and environmental factors, yet their …

Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms

S Massironi, G Mulinacci, C Gallo, A Elvevi, S Danese… - Cells, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders

JP Abonia, T Wen, EM Stucke, T Grotjan… - Journal of allergy and …, 2013 - Elsevier
Background Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease
mediated by immune hypersensitization to multiple foods and strongly associated with atopy …

Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing

JD Sherrill, K Kc, C Blanchard, EM Stucke… - Genes & …, 2014 - nature.com
Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus that is
compounded by genetic predisposition and hypersensitivity to environmental antigens …

Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis

ET Jensen, JT Kuhl, LJ Martin, ME Rothenberg… - Journal of Allergy and …, 2018 - Elsevier
Background Multiple lines of evidence point to the potential importance of early-life
environmental factors in the rapid increase in the incidence of eosinophilic esophagitis …

Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic …

AJ Lucendo, Á Arias, LC De Rezende… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Recent research shows that both pediatric and adult patients with
eosinophilic esophagitis (EoE) experience esophageal remodeling marked by increased …