Targeting eosinophils in allergy, inflammation and beyond
PC Fulkerson, ME Rothenberg - Nature reviews Drug discovery, 2013 - nature.com
Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …
in the blood and tissue is associated with several inflammatory and infectious diseases …
Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases
TX Lu, ME Rothenberg - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Allergic inflammation is accompanied by the coordinated expression of a myriad of genes
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling …
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling …
Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial
JM Spergel, ME Rothenberg, MH Collins… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic esophagitis is a chronic allergic disease with insufficient
treatment options. Results from animal studies suggest that IL-5 induces eosinophil …
treatment options. Results from animal studies suggest that IL-5 induces eosinophil …
Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis
ES Alexander, LJ Martin, MH Collins, LC Kottyan… - Journal of allergy and …, 2014 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic antigen-driven allergic inflammatory
disease, likely involving the interplay of genetic and environmental factors, yet their …
disease, likely involving the interplay of genetic and environmental factors, yet their …
Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets
F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …
High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
JP Abonia, T Wen, EM Stucke, T Grotjan… - Journal of allergy and …, 2013 - Elsevier
Background Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease
mediated by immune hypersensitization to multiple foods and strongly associated with atopy …
mediated by immune hypersensitization to multiple foods and strongly associated with atopy …
Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing
JD Sherrill, K Kc, C Blanchard, EM Stucke… - Genes & …, 2014 - nature.com
Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder of the esophagus that is
compounded by genetic predisposition and hypersensitivity to environmental antigens …
compounded by genetic predisposition and hypersensitivity to environmental antigens …
Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis
ET Jensen, JT Kuhl, LJ Martin, ME Rothenberg… - Journal of Allergy and …, 2018 - Elsevier
Background Multiple lines of evidence point to the potential importance of early-life
environmental factors in the rapid increase in the incidence of eosinophilic esophagitis …
environmental factors in the rapid increase in the incidence of eosinophilic esophagitis …
Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic …
AJ Lucendo, Á Arias, LC De Rezende… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Recent research shows that both pediatric and adult patients with
eosinophilic esophagitis (EoE) experience esophageal remodeling marked by increased …
eosinophilic esophagitis (EoE) experience esophageal remodeling marked by increased …