Vaccination continues to be the single most important and successful public health
intervention, due to its prevention of morbidity and mortality from prevalent infectious …

Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic
diseases that are characterized by an early onset and a profound block in the development …

Background This guideline from the European Academy of Allergy and Clinical Immunology
(EAACI) recommends approaches to prevent the development of immediate‐onset/IgE …

Summary Chromosome 22q11. 2 deletion syndrome is the most common microdeletion
syndrome in humans. The effects are protean and highly variable, making a unified …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting
children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis …

Background Newborns display distinct immune responses, leaving them vulnerable to
infections and impairing immunization. Targeting newborn dendritic cells (DCs), which …

Background Severe combined immunodeficiency (SCID) is fatal unless durable adaptive
immunity is established, most commonly through allogeneic haematopoietic cell …

Inherited defects in adenosine deaminase (ADA) cause a subtype of severe combined
immunodeficiency (SCID) known as severe combined immune deficiency caused by …

Immunisation of the newborn represents a key global strategy in overcoming morbidity and
mortality due to infection in early life. Potential limitations, however, include poor …