Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …

Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory
characteristics are incompletely understood. Objectives: To define the cytokine profile of …

Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

Summary Background Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6
regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease …

Alpha-1-antitrypsin (AAT), an acute-phase protein encoded by the SERPINA1 gene, is a
member of the serine protease inhibitor (SERPIN) superfamily. Its primary function is to …

Background SARS-CoV-2 infected patients show heterogeneous clinical presentations
ranging from mild symptoms to severe respiratory failure and death. Consequently, various …

Background: Epidemiologic studies have reported that the geographical distribution of the
prevalence of allelic variants of serine protein inhibitor-A1 (SERPINA1) and severe cases of …

Introduction Alpha1 antitrypsin deficiency (AATD), a common hereditary disorder affecting
mainly lungs, liver and skin has been the focus of some of the most exciting therapeutic …

With the improving survival of cystic fibrosis (CF) patients and the advent of highly effective
cystic fibrosis transmembrane conductance regulator (CFTR) therapy, the clinical spectrum …

Alpha-1-antitrypsin (AAT), a serine protease inhibitor (serpin), is increasingly recognized to
inhibit SARS-CoV-2 infection and counter many of the pathogenic mechanisms of COVID …