Diet is a critical element determining human health and diseases, and unbalanced food
habits are major risk factors for the development of obesity and related metabolic disorders …

Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …

Scope The high rates of overweight and obesity, currently occurring in children, underline
the urgent need for preventive strategies in early life before excess weight is gained …

Abstract “Western diet” containing high concentrations of sugar and fat consumed during
pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic …

Fasting is often used for obesity correction but the “refeeding syndrome” limits its efficiency,
and molecular mechanisms underlying metabolic response to different food availability are …

Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease worldwide, particularly in obese and type 2 diabetic individuals. NAFLD ranges in …

Research in both animals and humans shows that some nutrients are important in
pregnancy and during the first years of life to support brain and cognitive development. Our …

The preference for high-calorie foods depends on sex and contributes to obesity
development. Fibroblast growth factor 21 (FGF21) beneficially affects taste preferences and …

Ethnopharmacological relevance Passiflora edulis f. flavicarpa O. Deg. is a native Brazilian
fruit known as sour or yellow passion fruit. From its peel, mainly in the northeast of Brazil, is …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous
condition characterized by liver steatosis, inflammation, consequent fibrosis, and cirrhosis …