Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess
neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and …

Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting
the quality of patients' lives. They often have a genetic background, but oxidative stress and …

Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor …

Neurological and psychiatric disorders are a category of chronic diseases that are
widespread and pose serious mental and physical health problems for patients. The …

Aims The family of kynurenine pathway (KP) metabolites includes compounds produced
along two arms of the path and acting in clearly opposite ways. The equilibrium between …

The pathogenesis of Parkinson's disease (PD) remains to be elucidated. Metabolomic
analysis has the potential to identify biochemical pathways and metabolic profiles that are …

The kynurenine pathway (KP) is the major catabolic pathway for the essential amino acid
tryptophan leading to he production of nicotinamide adenine dinucleotide. In inflammatory …