A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …

Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …

Following successful gene rearrangement at αβ T-cell receptor (TCR) loci, developing
thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection …

Recent work has shown that RNA polymerase (Pol) II can be recruited to and transcribe
distal regulatory regions. Here we analyzed transcription initiation and elongation through …

Mammalian genomes are extensively transcribed outside the borders of protein-coding
genes. Genome-wide studies recently demonstrated that cis-regulatory genomic elements …

Abstract TCRαβ+ CD3+ CD4− CD8−“double negative”(DN) T cells comprise a small subset
of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and …

▪ Abstract The two major subsets of T lymphocytes in the peripheral immune system, the
helper and cytotoxic T cells, are defined by their expression of either the CD4 or the CD8 …

Recent research has uncovered complex transcription factor networks that control the
processes of T-cell development and differentiation. RUNX (runt-related transcription factor) …

To understand how CD8 expression is regulated during the transition process from CD4+
8+(CD4 and CD8 double positive, DP) to CD4− 8+(CD8 single positive, CD8SP) cells in the …

T cell immunity requires the long-term survival of T cells that are capable of recognizing self
antigens but are not overtly autoreactive. How this balance is achieved remains …