Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …

Cells acquire their ultimate identities by activating combinations of transcription factors that
initiate and sustain expression of the appropriate cell type-specific genes. T cell …

The blood system is maintained by a small pool of haematopoietic stem cells (HSCs), which
are required and sufficient for replenishing all human blood cell lineages at millions of cells …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells
(hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the …

According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors
(LMPPs)(Lin− Sca-1+ c-Kit+ CD34+ Flt3hi) and common myeloid progenitors (CMPs)(Lin …

In jawed vertebrates, development of an adaptive immune-system is essential for protection
of the born organism against otherwise life-threatening pathogens. Myeloid cells of the …

Cellular decision-making is mediated by a complex interplay of external stimuli with the
intracellular environment, in particular transcription factor regulatory networks. Here we have …

The differentiation of αβT cells from thymic precursors is a complex process essential for
adaptive immunity. Here we exploited the breadth of expression data sets from the …

Thymus development is critical to the adaptive immune system, yet a comprehensive
transcriptional framework capturing thymus organogenesis at single-cell resolution is still …