Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world.
Besides genetic causes, colonic inflammation is one of the major risk factors for CRC …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

Microbial products, such as lipopolysaccharide (LPS), can elicit efficient innate immune
responses against invading pathogens. However, priming with LPS can induce a form of …

Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …

The intestinal mucosa is constantly exposed to commensal microbes, opportunistic
pathogens, toxins, luminal components and other environmental stimuli. The intestinal …

As the first barrier of host defense, innate immunity sets up the parclose to keep out external
microbial or virus attacks. Depending on the type of pathogens, several cytoplasm pattern …

Colorectal cancer (CRC) has the third highest incidence and the second highest mortality in
the world, which seriously affects human health, while current treatments methods for CRC …

Activated inflammation and pyroptosis in macrophage are closely associated with acute lung
injury (ALI). Histone deacetylase 3 (HDAC3) serves as an important enzyme that could …

ABSTRACT Parasite-specific CD4+ Th1 cell responses are the predominant immune
effector for controlling malaria infection; however, the underlying regulatory mechanisms …

Myeloid-derived suppressor cells (MDSCs), the negative immune regulators, have been
demonstrated to be involved in immune responses to a variety of pathological conditions …