Mfsd8 localizes to endocytic compartments and influences the secretion of Cln5 and cathepsin D in Dictyostelium
RJ Huber, S Mathavarajah, SQ Yap - Cellular signalling, 2020 - Elsevier
The neuronal ceroid lipofuscinoses (NCLs) are a family of neurodegenerative diseases that
affect people of all ages and ethnicities, yet many of the associated genes/proteins are not …
affect people of all ages and ethnicities, yet many of the associated genes/proteins are not …
Inducible NAD (H)-linked methylglyoxal oxidoreductase regulates cellular methylglyoxal and pyruvate through enhanced activities of alcohol dehydrogenase and …
MK Kwak, MH Ku, SO Kang - Biochimica et Biophysica Acta (BBA)-General …, 2018 - Elsevier
Background High methylglyoxal content disrupts cell physiology, but mammals have
scavengers to prevent glycolytic and mitochondrial dysfunctions. In yeast, methylglyoxal …
scavengers to prevent glycolytic and mitochondrial dysfunctions. In yeast, methylglyoxal …
[HTML][HTML] Thymoquinone effect on the Dictyostelium discoideum model correlates with functional roles for glutathione S-transferases in eukaryotic proliferation …
N Alsaffar, Y Fang, E Walters - Plos one, 2023 - journals.plos.org
An increasing body of literature demonstrates the therapeutic relevance of polyphenols in
eukaryotic cell and animal model studies. The phase II glutathione S-transferases (GST) …
eukaryotic cell and animal model studies. The phase II glutathione S-transferases (GST) …
Curcumin inhibits development and cell adhesion in Dictyostelium discoideum: Implications for YakA signaling and GST enzyme function
M Garige, E Walters - Biochemical and Biophysical Research …, 2015 - Elsevier
The molecular basis for nutraceutical properties of the polyphenol curcumin (Curcuma
longa, Turmeric) is complex, affecting multiple factors that regulate cell signaling and …
longa, Turmeric) is complex, affecting multiple factors that regulate cell signaling and …
Schiff bases of putrescine with methylglyoxal protect from cellular damage caused by accumulation of methylglyoxal and reactive oxygen species in Dictyostelium …
SJ Park, MK Kwak, SO Kang - The International Journal of Biochemistry & …, 2017 - Elsevier
Polyamines protect protein glycation in cells against the advanced glycation end product
precursor methylglyoxal, which is inevitably produced during glycolysis, and the enzymes …
precursor methylglyoxal, which is inevitably produced during glycolysis, and the enzymes …
Candida albicans glutathione reductase downregulates Efg1-mediated cyclic AMP/protein kinase A pathway and leads to defective hyphal growth and virulence upon …
MH Ku, YU Baek, MK Kwak, SO Kang - Biochimica et Biophysica Acta (BBA …, 2017 - Elsevier
Background Glutathione reductase maintains the glutathione level in a reduced state. As
previously demonstrated, glutathione is required for cell growth/division and its …
previously demonstrated, glutathione is required for cell growth/division and its …
[HTML][HTML] Methylglyoxal-Scavenging Enzyme Activities Trigger Erythroascorbate Peroxidase and Cytochrome c Peroxidase in Glutathione-Depleted Candida albicans
SO Kang, MK Kwak - Journal of Microbiology and Biotechnology, 2021 - ncbi.nlm.nih.gov
Abstract γ-Glutamylcysteine synthetase (Gcs1) and glutathione reductase (Glr1) activity
maintains minimal levels of cellular methylglyoxal in Candida albicans. In glutathione …
maintains minimal levels of cellular methylglyoxal in Candida albicans. In glutathione …
Polyamines regulate cell growth and cellular methylglyoxal in high‐glucose medium independently of intracellular glutathione
MK Kwak, MH Lee, SJ Park, SM Shin, R Liu… - FEBS …, 2016 - Wiley Online Library
Polyamines can presumably inhibit protein glycation, when associated with the
methylglyoxal inevitably produced during glycolysis. Herein, we hypothesized a …
methylglyoxal inevitably produced during glycolysis. Herein, we hypothesized a …
[HTML][HTML] Characterization of glutathione S-transferase enzymes in Dictyostelium discoideum suggests a functional role for the GSTA2 isozyme in cell proliferation and …
M Garige, E Walters - Plos one, 2021 - journals.plos.org
In this report, we extend our previous characterization of Dictyostelium discoideum
glutathione S-transferase (DdGST) enzymes that are expressed in the eukaryotic model …
glutathione S-transferase (DdGST) enzymes that are expressed in the eukaryotic model …
Alcohol dehydrogenase 1 and NAD(H)-linked methylglyoxal oxidoreductase reciprocally regulate glutathione-dependent enzyme activities in Candida albicans
SO Kang, MK Kwak - Journal of Microbiology, 2021 - Springer
Glutathione reductase (Glr1) activity controls cellular glutathione and reactive oxygen
species (ROS). We previously demonstrated two predominant methylglyoxal scavengers …
species (ROS). We previously demonstrated two predominant methylglyoxal scavengers …