Alpha-2-macroglobulin is an extracellular macromolecule mainly known for its role as a
broad-spectrum protease inhibitor. By presenting itself as an optimal substrate for …

The 78 kDa glucose‐regulated protein (GRP78) is an endoplasmic reticulum (ER)‐resident
molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Cancer photothermal (PTT) and photodynamic therapies (PDT) have aroused tremendous
attention with high spatial specificity, but they experience the challenges from the inefficient …

Hepatocellular carcinoma (HCC) takes the predominant malignancy of hepatocytes with
bleak outcomes owing to high heterogeneity among patients. Personalized treatments …

Coronavirus disease (COVID-19)-associated mucormycosis (CAM) is an emerging threat
globally, especially in India. More than 40,000 CAM cases have been reported in India. The …

Heat shock proteins are molecular chaperones which support tumor development by
regulating various cellular processes including unfolded protein response, mitochondrial …

Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is
predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial …

The effective treatment of glioma through conventional chemotherapy is proved to be a great
challenge in clinics. The main reason is due to the existence of two physiological and …

Breast cancer is the most common type of cancer and it is treated with surgical intervention,
radiotherapy, chemotherapy, or a combination of these regimens. Despite chemotherapy's …