[HTML][HTML] In vitro and in silico evaluation of the antimicrobial and antioxidant activities of spiropyrazoline oxindole congeners

M Chalkha, K Chebbac, H Nour, A Nakkabi… - Arabian Journal of …, 2024 - Elsevier
The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic
field in medicinal chemistry. In this context, a series of spiropyrazoline indolin-3-one …

Construction of Fe3O4@ α-glucosidase magnetic nanoparticles for ligand fishing of α-glucosidase inhibitors from a natural tonic Epimedii Folium

Y Shen, M Wang, J Zhou, Y Chen, M Wu, Z Yang… - International Journal of …, 2020 - Elsevier
Inhibition of α-glucosidase activity is an effective way for treatment of type 2 diabetes
mellitus. Epimedii Folium is an important source of α-glucosidase inhibitors (AGIs), however …

Recent advances in the synthesis of benzo [b] furans

MM Heravi, V Zadsirjan - Advances in Heterocyclic Chemistry, 2024 - Elsevier
Benzo [b] furan structure is found in different naturally occurring and biologically active
compounds. Benzo [b] furan derivatives are of interest due to their anticancer, anti …

Computational study and in vitro alpha-glucosidase inhibitory effects of medicinal plants from a Thai folk remedy

K Eawsakul, P Panichayupakaranant, T Ongtanasup… - Heliyon, 2021 - cell.com
The number of patients with type 2 diabetes mellitus (T2DM) has increased worldwide.
Although an instant cure was achieved with the standard treatment acabose, unsatisfactory …

Experimental and theoretical insights into free radical capturing activity of 1, 5-diaminonaphthalene and 1, 5-dihydroxynaphthalene

DQ Huong, PC Nam, T Duong - Journal of Molecular Structure, 2023 - Elsevier
The radical scavenging activity of two naphthalene derivatives, 1, 5-diaminonaphthalene
(DAN) and 1, 5-diaminonaphthalene (DAN) and 1, 5-dihydroxynaphthalene (DHN), was …

Effectiveness of cyclohexyl functionality in ugonins from Helminthostachys zeylanica to PTP1B and α-glucosidase inhibitions

AB Shah, S Yoon, JH Kim, K Zhumanova… - International Journal of …, 2020 - Elsevier
Ugonins are unique flavonoids with cyclohexyl motif from Helminthostachys zeylanica.
Ugonins (1–6) from the target plant displayed significant inhibitions against both PTP1B (IC …

Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin

D Wu, X Hu, Z Cai, J Zhang, F Geng, H Li - Food & Function, 2023 - pubs.rsc.org
It has been reported in many studies that piperine (PIP) has multiple activity properties, the
most prominent of which is antioxidant activity. This work reports the binding behavior and …

Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents

IG Asuquo, M Solangi, KM Khan… - Future Medicinal …, 2023 - Taylor & Francis
Background: Diabetes mellitus is a serious global health concern, and this is expected to
impact more than 300 million people by 2025. The current study focuses on identifying …

Biotransformation and bioaccessibility of active ingredients from Radix Astragali by Poria cocos during solid-state fermentation and in vitro digestion and antioxidant …

CY Chen, R Zhang, LJ Zhang, ZY Hu, SP Wang… - Scientific Reports, 2023 - nature.com
Radix Astragali is one of the most famous and frequently used health food supplements and
herbal medicines. Among more than 227 components of Radix Astragali, Astragaloside IV …

New Derivatives of 1-(3-Methyl-1-Benzofuran-2-yl) Ethan-1-one: Synthesis and Preliminary Studies of Biological Activity

M Napiórkowska, P Kumaravel… - International Journal of …, 2024 - mdpi.com
A set of nine derivatives, including five brominated compounds, was synthesized and the
structures of these novel compounds were confirmed using 1H and 13C NMR as well as ESI …