This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …

Polygenic diseases are caused by the joint contribution of a number of independently acting
or interacting polymorphic genes; the individual contribution of each gene may be small or …

Complex multivariate testing problems are frequently encountered in many scientific
disciplines, such as engineering, medicine and the social sciences. As a result, modern …

The clinical diagnosis of progressive supranuclear palsy (PSP) relies on the identification of
characteristic signs and symptoms. A proportion of pathologically diagnosed cases do not …

Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human
aging. To determine whether variation in the human KLOTHO locus contributes to survival …

Despite recent advances in the molecular genetics of type 2 diabetes, the majority of
susceptibility genes in humans remain to be identified. We therefore conducted a 10-cM …

It has become commonplace in the statistical analysis of genetic data to use Monte Carlo
procedures to calculate empirical P values. The reasons for this include the following:(1) …

Osteoarthritis (OA) is a leading cause of disability in Western society with multiple risk
factors, including a complex genetic pattern. Identifying loci involved in the heredity of OA …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

Purpose: There is an increase in the incidence of Achilles tendon injuries as a result of the
participation in physical activity. It has been suggested that some individuals have a genetic …