The dopamine D3 receptor, a quarter century later
P Sokoloff, B Le Foll - European Journal of Neuroscience, 2017 - Wiley Online Library
This review updates the existing knowledge suggesting a role for the D3 receptor in
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …
schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling …
Neuronal dopamine D3 receptors: translational implications for preclinical research and CNS disorders
B Kiss, I Laszlovszky, B Krámos, A Visegrády, A Bobok… - Biomolecules, 2021 - mdpi.com
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …
and periphery, exerts its actions through five types of receptors which belong to two major …
Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography
The striatum acts in conjunction with the cortex to control and execute functions that are
impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and …
impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and …
Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy
AC Tziortzi, GE Searle, S Tzimopoulou, C Salinas… - Neuroimage, 2011 - Elsevier
[11C]-(+)-PHNO is a D3 preferring PET radioligand which has recently opened the
possibility of imaging D3 receptors in the human brain in vivo. This imaging tool allows …
possibility of imaging D3 receptors in the human brain in vivo. This imaging tool allows …
Increased stress-induced dopamine release in psychosis
BACKGROUND: A pathologic response to common life stressors, in which a
hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic …
hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic …
Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling
L Cavalleri, E Merlo Pich, MJ Millan, C Chiamulera… - Molecular …, 2018 - nature.com
Among neurobiological mechanisms underlying antidepressant properties of ketamine,
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …
structural remodeling of prefrontal and hippocampal neurons has been proposed as critical …
Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain
Caffeine, the most widely consumed psychoactive substance in the world, is used to
promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants …
promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants …
Striatal dopamine D2/D3 receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans
DG Ghahremani, B Lee, CL Robertson… - Journal of …, 2012 - Soc Neuroscience
Impulsive behavior is thought to reflect a traitlike characteristic that can have broad
consequences for an individual's success and well-being, but its neurobiological basis …
consequences for an individual's success and well-being, but its neurobiological basis …
Deficits in striatal dopamine release in cannabis dependence
Most drugs of abuse lead to a general blunting of dopamine release in the chronic phase of
dependence, which contributes to poor outcome. To test whether cannabis dependence is …
dependence, which contributes to poor outcome. To test whether cannabis dependence is …
Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [11C]-(+)-PHNO
Rationale Second-generation antipsychotics occupy dopamine D 2 receptors and act as
antagonists or partial agonists at these receptors. While these drugs alleviate positive …
antagonists or partial agonists at these receptors. While these drugs alleviate positive …