According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Identifying the interactions established by a protein of interest can be a critical step in
understanding its function. This is especially true when an unknown protein of interest is …

Accurate descriptions of protein-protein interactions are essential for understanding
biological systems. Remarkably accurate atomic structures have been recently computed for …

Current yeast interactome network maps contain several hundred molecular complexes with
limited and somewhat controversial representation of direct binary interactions. We carried …

When duplex DNA is altered in almost any way (replicated, recombined, or repaired), single
strands of DNA are usually intermediates, and single-stranded DNA binding (SSB) proteins …

The genome of Mycoplasma pneumoniae is among the smallest found in self-replicating
organisms. To study the basic principles of bacterial proteome organization, we used …

The broad range of cellular activities carried out by Fe–S proteins means that they have a
central role in the life of most organisms. At the interface between biology and chemistry …

Efforts to map the Escherichia coli interactome have identified several hundred
macromolecular complexes, but direct binary protein-protein interactions (PPIs) have not …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

One-third of the 4,225 protein-coding genes of Escherichia coli K-12 remain functionally
unannotated (orphans). Many map to distant clades such as Archaea, suggesting …