The molecular and cellular strategies of glioblastoma and non-small-cell lung cancer cells conferring radioresistance
Ionizing radiation (IR) has been shown to play a crucial role in the treatment of glioblastoma
(GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies …
(GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies …
Characteristics of anticancer activity of CBP/p300 inhibitors–Features of their classes, intracellular targets and future perspectives of their application in cancer …
M Strachowska, A Robaszkiewicz - Pharmacology & Therapeutics, 2024 - Elsevier
Due to the contribution of highly homologous acetyltransferases CBP and p300 to
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …
transcription elevation of oncogenes and other cancer promoting factors, these enzymes …
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response
S Faletti, D Osti, E Ceccacci, C Richichi… - Science Translational …, 2021 - science.org
Glioblastoma (GBM) is a fatal tumor whose aggressiveness, heterogeneity, poor blood-brain
barrier penetration, and resistance to therapy highlight the need for new targets and clinical …
barrier penetration, and resistance to therapy highlight the need for new targets and clinical …
Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model
EA Adjei‐Sowah, SA O'Connor, J Veldhuizen… - Advanced …, 2022 - Wiley Online Library
The perivascular niche (PVN) is a glioblastoma tumor microenvironment (TME) that serves
as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to …
as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to …
Newly established patient-derived organoid model of intracranial meningioma
S Yamazaki, F Ohka, M Hirano, Y Shiraki… - Neuro …, 2021 - academic.oup.com
Background Recent comprehensive studies have revealed several molecular alterations
that are frequently found in meningiomas. However, effective treatment reagents targeting …
that are frequently found in meningiomas. However, effective treatment reagents targeting …
Upregulation of LINC00501 by H3K27 acetylation facilitates gastric cancer metastasis through activating epithelial‐mesenchymal transition and angiogenesis
R Dou, L Han, C Yang, Y Fang, J Zheng… - Clinical and …, 2023 - Wiley Online Library
Background The molecular mechanism of the significant role of long noncoding RNAs
(lncRNAs) in the progression and metastasis of gastric cancer (GC) remains largely elusive …
(lncRNAs) in the progression and metastasis of gastric cancer (GC) remains largely elusive …
Glioblastoma stem cells deliver ABCB4 transcribed by ATF3 via exosomes conferring glioblastoma resistance to temozolomide
X Xu, Y Zheng, L Luo, Z You, H Chen, J Wang… - Cell Death & …, 2024 - nature.com
Glioblastoma stem cells (GSCs) play a key role in glioblastoma (GBM) resistance to
temozolomide (TMZ) chemotherapy. With the increase in research on the tumour …
temozolomide (TMZ) chemotherapy. With the increase in research on the tumour …
[HTML][HTML] RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer
S Zhang, J Wang, W Hu, L He, Q Tang, J Li, M Jie, X Li… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Forkhead box M1 (FOXM1) plays a critical role in development physiologically and
tumorigenesis pathologically. However, insufficient efforts have been dedicated to exploring …
tumorigenesis pathologically. However, insufficient efforts have been dedicated to exploring …
Transcription factors with targeting potential in gliomas
AI Giannopoulou, DS Kanakoglou, C Piperi - International Journal of …, 2022 - mdpi.com
Gliomas portray a large and heterogeneous group of CNS tumors, encompassing a wide
range of low-to high-grade tumors, as defined by histological and molecular characteristics …
range of low-to high-grade tumors, as defined by histological and molecular characteristics …
Targeting histone epigenetic modifications and DNA damage responses in synthetic lethality strategies in cancer?
PA Lazo - Cancers, 2022 - mdpi.com
Simple Summary Dynamic chromatin remodeling is regulated by different epigenetic
modifications of histones to adapt chromatin to specific cellular functions. Targeting histone …
modifications of histones to adapt chromatin to specific cellular functions. Targeting histone …