Endosome dysregulation in down syndrome: a potential contributor to Alzheimer disease pathology

A Filippone, D Praticò - Annals of neurology, 2021 - Wiley Online Library
Intracellular protein trafficking via the endosomes plays a key role in the maintenance of
normal neuronal function. Although many diseases of the central nervous system exhibit …

The structural basis of IRF-3 activation upon phosphorylation

T Jing, B Zhao, P Xu, X Gao, L Chi, H Han… - The Journal of …, 2020 - journals.aai.org
The innate immune system is the first line of defense against bacterial and viral infections.
The recognition of pathogen-associated molecular patterns by the RIG-I–like receptors …