In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Circulating tumor cells (CTCs) are tumor cells that shed from the primary tumor and
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …

Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …

The analysis of circulating tumor cells (CTCs) is an outstanding tool to provide insights into
the biology of metastatic cancers, to monitor disease progression and with potential for use …

Chemotherapy sometimes can cause potential tumor-specific T-cell-mediated immune
response via stimulating immunogenic cell death (ICD). However, such immune response is …

Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Breast cancer is one of the most prevalent malignancies in women worldwide. Early-stage
breast cancer is considered a curable disease; however, once distant metastasis occurs, the …

Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …