Extracellular vesicles as biomarkers in liver diseases: a clinician's point of view
S Thietart, PE Rautou - Journal of hepatology, 2020 - Elsevier
Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and
microRNAs. They can originate from both healthy and stressed cells, and provide a …
microRNAs. They can originate from both healthy and stressed cells, and provide a …
Alcoholic liver disease: alcohol metabolism, cascade of molecular mechanisms, cellular targets, and clinical aspects
R Teschke - Biomedicines, 2018 - mdpi.com
Alcoholic liver disease is the result of cascade events, which clinically first lead to alcoholic
fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to …
fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to …
[PDF][PDF] Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR‐23a‐3p and up‐regulate programmed death ligand 1 expression in …
Endoplasmic reticulum (ER) stress promotes tumor cell escape from immunosurveillance.
However, the underlying mechanisms remain unknown. We hypothesized that ER stress …
However, the underlying mechanisms remain unknown. We hypothesized that ER stress …
What is the blood concentration of extracellular vesicles? Implications for the use of extracellular vesicles as blood-borne biomarkers of cancer
Circulating biomarkers have a great potential in diagnosing cancer diseases at early stages,
where curative treatment is a realistic possibility. In the recent years, using extracellular …
where curative treatment is a realistic possibility. In the recent years, using extracellular …
Fructose promotes leaky gut, endotoxemia, and liver fibrosis through ethanol‐inducible cytochrome P450‐2E1–mediated oxidative and nitrative stress
Fructose intake is known to induce obesity, insulin resistance, metabolic syndrome, and
nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose …
nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose …
Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease
C Yan, W Hu, J Tu, J Li, Q Liang, S Han - Journal of Translational …, 2023 - Springer
Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …
Phosphatidylethanol (PEth) in blood as a marker of unhealthy alcohol use: a systematic review with novel molecular insights
M Perilli, F Toselli, L Franceschetto, A Cinquetti… - International Journal of …, 2023 - mdpi.com
The Alcohol Use Disorders Identification Test (AUDIT) and its short form, the AUDIT-C, the
main clinical instruments used to identify unhealthy drinking behaviors, are influenced by …
main clinical instruments used to identify unhealthy drinking behaviors, are influenced by …
[PDF][PDF] Mitochondrial double‐stranded RNA in exosome promotes Interleukin‐17 production through toll‐like receptor 3 in alcohol‐associated liver injury
Background and Aims Mitochondrial double‐stranded RNA (mtdsRNA) and its innate
immune responses have been reported previously; however, mtdsRNA generation and its …
immune responses have been reported previously; however, mtdsRNA generation and its …
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Y Yang, P Sangwung, R Kondo, Y Jung… - Journal of …, 2021 - Elsevier
Background & Aims Liver sinusoidal endothelial cell (LSEC) dysfunction has been reported
in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus …
in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus …
Pathogenesis of alcohol-associated liver disease
Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …