The FGF family: biology, pathophysiology and therapy
A Beenken, M Mohammadi - Nature reviews Drug discovery, 2009 - nature.com
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …
processes, including brain patterning, branching morphogenesis and limb development …
Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
R Ruan, L Li, X Li, C Huang, Z Zhang, H Zhong… - Molecular Cancer, 2023 - Springer
Abstract Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a
crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving …
crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving …
Single-cell analysis of blood-brain barrier response to pericyte loss
MA Mäe, L He, S Nordling… - Circulation …, 2021 - Am Heart Assoc
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …
vessels during development and tissue repair. Loss of pericytes has been described in …
Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models
M Qi, S Fan, M Huang, J Pan, Y Li… - The Journal of …, 2023 - Am Soc Clin Investig
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis
(CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel …
(CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel …
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …
Evolution of the Fgf and Fgfr gene families
N Itoh, DM Ornitz - TRENDS in Genetics, 2004 - cell.com
Fibroblast growth factors (Fgfs) and Fgf receptors (Fgfrs) comprise a signaling system that is
conserved throughout metazoan evolution. Twenty-two Fgfs and four Fgfrs have been …
conserved throughout metazoan evolution. Twenty-two Fgfs and four Fgfrs have been …
Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development
A Aigner, PE Ray, F Czubayko, A Wellstein - Histochemistry and cell …, 2002 - Springer
Fibroblast growth factors (FGFs) play important roles during fetal and embryonic
development. FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been …
development. FGF-2 (basic FGF, bFGF) is widely expressed in the embryo and has been …
The role of fibroblast growth factors in tumor growth
M Korc, RE Friesel - Current cancer drug targets, 2009 - ingentaconnect.com
Biological processes that drive cell growth are exciting targets for cancer therapy. The
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …
fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell …
Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis
Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival,
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …
angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in …
[HTML][HTML] Molecular and clinical significance of fibroblast growth factor 2 (FGF2/bFGF) in malignancies of solid and hematological cancers for personalized therapies
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …
Mammalian FGF family members participate in multiple signaling pathways by binding to …