The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies

AT Amare, KO Schubert, M Klingler-Hoffmann… - Translational …, 2017 - nature.com
Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

CM Yates, PC Calder, GE Rainger - Pharmacology & therapeutics, 2014 - Elsevier
Abstract Omega-3 (n− 3) polyunsaturated fatty acids (n− 3 PUFAs) have well documented
anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory …

Identification of type 2 diabetes loci in 433,540 East Asian individuals

CN Spracklen, M Horikoshi, YJ Kim, K Lin, F Bragg… - Nature, 2020 - nature.com
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease

W Wang, M Hu, H Liu, X Zhang, H Li, F Zhou, YM Liu… - Cell metabolism, 2021 - cell.com
Metabolic dysfunction is becoming a predominant risk for the development of many
comorbidities. Ischemic heart disease (IHD) still imposes the highest disease burden among …

The Korea Biobank Array: design and identification of coding variants associated with blood biochemical traits

S Moon, YJ Kim, S Han, MY Hwang, DM Shin… - Scientific reports, 2019 - nature.com
We introduce the design and implementation of a new array, the Korea Biobank Array
(referred to as KoreanChip), optimized for the Korean population and demonstrate findings …

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

VL Chen, X Du, Y Chen, A Kuppa… - Nature …, 2021 - nature.com
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver
disease, a major cause of mortality. We conduct a meta-analysis of genome-wide …

A genome-wide association study of the human metabolome in a community-based cohort

EP Rhee, JE Ho, MH Chen, D Shen, S Cheng… - Cell metabolism, 2013 - cell.com
Because metabolites are hypothesized to play key roles as markers and effectors of
cardiometabolic diseases, recent studies have sought to annotate the genetic determinants …

A large multiethnic genome-wide association study of adult body mass index identifies novel loci

TJ Hoffmann, H Choquet, J Yin, Y Banda, MN Kvale… - Genetics, 2018 - academic.oup.com
Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

Branched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations

T Chen, Y Ni, X Ma, Y Bao, J Liu, F Huang, C Hu… - Scientific reports, 2016 - nature.com
Recent studies revealed strong evidence that branched-chain and aromatic amino acids
(BCAAs and AAAs) are closely associated with the risk of developing type 2 diabetes in …

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

Y Okada, X Sim, MJ Go, JY Wu, D Gu, F Takeuchi… - Nature …, 2012 - nature.com
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health
problem, and the assessment of genetic factors influencing kidney function has substantial …