Introduction: Among the dimethanesulfonates, busulfan, in combination with other alkylating
agents or nucleoside analogues, is the cornerstone of high-dose chemotherapy. It is used …

DNA adducting drugs, including alkylating agents and platinum-containing drugs, are
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …

Butadiene (BD) is an important industrial and environmental chemical classified as a human
carcinogen based on epidemiologic studies in occupationally exposed workers and animal …

The main method of evaluating the DNA interstrand cross-linking ability of cancer
chemotherapeutic agents in naked DNA currently involves the electrophoresis of relatively …

1, 2, 3, 4-Diepoxybutane (DEB) is a bifunctional electrophile capable of forming DNA− DNA
and DNA− protein cross-links. DNA alkylation by DEB produces N7-(2 '-hydroxy-3 ', 4 ' …

The postmeiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the
genomic effects of environmental mutagens because as male germ cells form mature sperm …

1, 2, 3, 4-Diepoxybutane (DEB) is a key carcinogenic metabolite of the important industrial
chemical 1, 3-butadiene. DEB is a bifunctional alkylating agent capable of reacting with DNA …

Smoking is a leading cause of lung cancer, accounting for 81% of lung cancer cases.
Tobacco smoke contains over 5000 compounds, of which more than 70 have been …

1, 2, 3, 4-Diepoxybutane (DEB) is a prominent carcinogenic metabolite of 1, 3-butadiene (1,
3-BD), an important industrial chemical and an environmental pollutant found in cigarette …

DNA–protein cross‐links (DPC s) are unusually bulky DNA adducts that form in cells as a
result of exposure to endogenous and exogenous agents including reactive oxygen species …