Obesity and diabetes has become a major epidemic across the globe. Controlling obesity
has been a challenge since this would require either increased physical activity or reduced …

Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells
in obesity, while focusing on glucose and fatty acid metabolism, shows many common …

Thermogenesis in endotherms relies on both shivering and non-shivering thermogenesis
(NST). The role of brown adipose tissue (BAT) in NST is well recognized, but the role of …

Sarcolipin (SLN) is a small regulatory protein that inhibits the sarco (endo) plasmic reticulum
Ca2+-ATPase (SERCA) pump. When bound to SERCA, SLN reduces the apparent Ca2+ …

Skeletal muscle has been suggested as a site of nonshivering thermogenesis (NST) besides
brown adipose tissue (BAT). Studies in birds, which do not contain BAT, have demonstrated …

Patients with ALS show, in addition to the loss of motor neurons in the spinal cord,
brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside …

Background Sarcolipin and uncoupling protein 3 (UCP3) mediate muscle-based non-
shivering thermogenesis (NST) to improve metabolic homeostasis. The impacts of maternal …

We have used FRET-based biosensors in live cells, in a robust high-throughput screening
(HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac …

Sarcolipin (SLN) is a regulator of sarco/endo plasmic reticulum Ca2+-ATPase (SERCA)
pump and has been shown to be involved in muscle nonshivering thermogenesis (NST) and …

Obesity is a chronic disease derived from disequilibrium between energy intake and energy
expenditure and evolving as a challenging epidemiological disease in the 21st century. It is …