Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Y Ohue, H Nishikawa - Cancer science, 2019 - Wiley Online Library
Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self‐and
nonself‐antigens to maintain immune homeostasis. In tumor immunity, Treg cells are …
nonself‐antigens to maintain immune homeostasis. In tumor immunity, Treg cells are …
[HTML][HTML] Identifying and targeting human tumor antigens for T cell-based immunotherapy of solid tumors
V Leko, SA Rosenberg - Cancer Cell, 2020 - cell.com
Cancer elimination in humans can be achieved with immunotherapy that relies on T
lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have …
lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have …
[HTML][HTML] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
S Kumagai, S Koyama, K Itahashi, T Tanegashima… - Cancer Cell, 2022 - cell.com
The balance of programmed death-1 (PD-1)-expressing CD8+ T cells and regulatory T
(Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …
(Treg) cells in the tumor microenvironment (TME) determines the clinical efficacy of PD-1 …
Regulatory T cells in cancer immunosuppression—implications for anticancer therapy
Y Togashi, K Shitara, H Nishikawa - Nature reviews Clinical oncology, 2019 - nature.com
Regulatory T (Treg) cells, an immunosuppressive subset of CD4+ T cells characterized by
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
Anatomically distinct fibroblast subsets determine skin autoimmune patterns
The skin serves as a physical barrier and an immunological interface that protects the body
from the external environment,–. Aberrant activation of immune cells can induce common …
from the external environment,–. Aberrant activation of immune cells can induce common …
Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
Targeting Treg cells in cancer immunotherapy
A Tanaka, S Sakaguchi - European journal of immunology, 2019 - Wiley Online Library
Foxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
Human FOXP3+ regulatory T cell heterogeneity and function in autoimmunity and cancer
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
CTLA-4: a moving target in immunotherapy
B Rowshanravan, N Halliday… - Blood, The Journal of …, 2018 - ashpublications.org
CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are
responsible for various aspects of T-cell immune regulation. The family includes CD28 …
responsible for various aspects of T-cell immune regulation. The family includes CD28 …